The force-frequency relationship: insights from mathematical modeling
نویسندگان
چکیده
منابع مشابه
The force-frequency relationship: insights from mathematical modeling.
The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple formulation of Koch-Wesser and Blinks in 1963 to the most sophisticated ones of today. This property of cardiac muscle is amplified by β-adrenergic stimulation, and, in a coordinated ...
متن کاملHistorical Perspectives The force-frequency relationship: insights from mathematical modeling
Puglisi JL, Negroni JA, Chen-Izu Y, Bers DM. The forcefrequency relationship: insights from mathematical modeling. Adv Physiol Educ 37: 28–34, 2013; doi:10.1152/advan.00072.2011.—The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple form...
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a reduced force of contraction in vivo and in vitro. The present study was aimed to investigate whether inotropic stimulation influences the inverse force-frequency relationship in failing human myocardium. Methods and Results. The effects of the cAMP-independent positive inotropic agents ouabain (0.01 ,imol/L) and BDF 9148 (0.1 ,umol/L) as well as the 3-adrenoceptor agonist isoprenaline (0.01 ...
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ژورنال
عنوان ژورنال: Advances in Physiology Education
سال: 2013
ISSN: 1043-4046,1522-1229
DOI: 10.1152/advan.00072.2011